Pro-Myristic Acid

Negative control for MiTMAB™ and OcTMAB™

Pack Size

Biological Description Negative control molecule for use with MiTMAB™ (Asc-466) and OcTMAB™ (Asc-467). Pro-Myristic acid is an in vitro inhibitor of dynamin I and II, targeting the PH (lipid binding) domain (IC₅₀ = 9.2 µM for inhibition of dynamin I GTPase). Although cell permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor (IC₅₀ = ≥300 µM for receptor-mediated endocytosis). It can therefore be used as a negative control in cell-based studies with MiTMAB™ and/or OcTMAB™.
Useful References
Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. abstract
Chemical Information 2-(Dimethylamino)ethyl tetradecanoate
	Store at RT MW 299.50 Soluble in DMSO to 25 mM and in ethanol to 100 mM C₁₈H₃₇NO₂ 43016-78-0
Additional Information Sold under exclusive licence from Children’s Medical Research Institute and Newcastle Innovation Ltd.