Purvalanol B
CDK2 inhibitorProduct Code: Asc-305 |
Purity: >98% |
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Biological DescriptionPotent CDK2 inhibitor, displaying an IC50 against the complex of CDK2-cyclin A of 6 nM. Shows selectivity over a range of other protein kinases including protein kinase C, Raf kinase, and casein kinase2. |
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Useful References | |
Gray et al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr Med Chem. 6:859-75 abstract Gray et al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281: 533-38 abstract Chang et al (1999) Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem Biol. 6:361-75 abstract | |
Chemical Information4-(2-((R)-1-Hydroxy-3-methylbutan-2-ylamino)-9-isopropyl-9H-purin-6-ylamino)-2-chlorobenzoic acid | |
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