QX-314 bromide (<em>N</em>-Ethyllidocaine bromide) (mM/ml) Supplier | Abcam Biochemicals® | High Quality Biochemicals
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QX-314 bromide (<em>N</em>-Ethyllidocaine bromide) (mM/ml)

Na+ channel blocker. 1 ml water soluble pack.

Other names: N-Ethyllidocaine bromide

Product Code: Asc-4492

Purity: >99%

 
Pack Size

 

100mM (1ml)

Buy QX-314 bromide (<em>N</em>-Ethyllidocaine bromide) (mM/ml) from Abcam
Biological Description

A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly.

Soluble in 1 ml water to give specified mM/ml concentration. Find out more.

Useful References

(1994) Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells. Neurosci Lett. 172:73-96 abstract

(1993) Inhibition of brain cell excitability by lidocaine, QX314, and tetrodotoxin: a mechanism for analgesia from infused local anesthetics? 1993 Acta Anaesthesiol Scand.37:516-23 abstract

(1973)The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol. 62:37-57 abstract

Citations

Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel?mediated modulation of glutamatergic synaptic transmission in midbrain abstract

Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons abstract

Pre-and postsynaptic properties of glutamatergic transmission in the immature inhibitory MNTB-LSO pathway abstract

Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus abstract

N?arachidonyl?glycine modulates synaptic transmission in superficial dorsal horn abstract

Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. abstract

Novel GABAergic Circuits Mediating Excitation/Inhibition of Cajal-Retzius Cells in the Developing Hippocampus abstract

Serotonergic modulation of neuronal activity in rat midbrain periaqueductal grey. abstract

Chemical Information

N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide

Asc-4492
  • Desiccate at +4°C
  • MW 343.31
  • Soluble in 1 ml water to give specified mM/ml concentration
  • C16H27BrN2O
  • 21306-56-9