QX-314 chloride (<em>N</em>-Ethyllidocaine chloride) (mM/ml) Supplier | Abcam Biochemicals® | High Quality Biochemicals
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QX-314 chloride (<em>N</em>-Ethyllidocaine chloride) (mM/ml)

Na+ channel blocker. 1 ml water soluble pack.

Other names: N-Ethyllidocaine chloride

Product Code: Asc-4493

Purity: >99%

 
Pack Size

 

100mM (1ml)

Buy QX-314 chloride (<em>N</em>-Ethyllidocaine chloride) (mM/ml) from Abcam
Biological Description

A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ channels.

Soluble in 1 ml water to give specified mM/ml concentration. Find out more.

Useful References

(1994) Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells. Neurosci Lett. 172:73-96 abstract

(1993) Inhibition of brain cell excitability by lidocaine, QX314, and tetrodotoxin: a mechanism for analgesia from infused local anesthetics? 1993 Acta Anaesthesiol Scand.37:516-23 abstract

(1973)The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol. 62:37-57 abstract

Citations

Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission abstract

Cholecystokinin exerts an effect via the endocannabinoid system to inhibit GABAergic transmission in midbrain periaqueductal gray abstract

Pre-and postsynaptic properties of glutamatergic transmission in the immature inhibitory MNTB-LSO pathway abstract

Synaptic Zn2+ Inhibits Neurotransmitter Release by Promoting Endocannabinoid Synthesis abstract

Chemical Information

N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride

Asc-4493
  • Desiccate at +4°C
  • MW 298.85
  • Soluble in 1 ml water to give specified mM/ml concentration
  • C16H27ClN2O
  • 5369-03-9