(R,S)-Rolipram

Selective PDE4 inhibitor

Pack Size

Biological Description Selective cAMP-specific phosphodiesterase PDE4 inhibitor (IC₅₀ values are 1.1 μM and 0.17 μM for inhibition of mouse PDE4A1 and PDE4B respectively)
Useful References
Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127:105 abstract Zhu et al (2001) The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev. 7:387 abstract Cherry et al (2001) Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. Biochim Biophys Acta 1518:27 abstract
Citations
Shelly et al (2010) Local and Long-Range Reciprocal Regulation of cAMP and cGMP in Axon/Dendrite Formation. Science. 327:547-52. abstract
Chemical Information (R,S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
	Desiccate at +4°C MW 275.35 Soluble in DMSO to 100 mM and in ethanol to 100 mM C₁₆H₂₁NO₃ 61413-54-5