Rasagiline mesylate
MAO-B inhibitorOther names: Azilect | |||||
Product Code: Asc-236 |
Purity: >99% |
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| Buy Rasagiline mesylate from Abcam | ||||
Biological DescriptionSelective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins. |
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Useful References | |
Youdim et al (2001) Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol.21:555-73 abstract Mandel et al (2005) Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives. Brain Res Brain Res Rev. 48:379-87 abstract Weinreb et al (2009) Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain. J Neural Transm. 2009 Apr 25. [Epub ahead of print] abstract | |
Chemical Information(1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-Inden-1-amine methanesulfonate | |
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