Rottlerin
Kinase inhibitorProduct Code: Asc-377 |
Purity: >95% |
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Biological DescriptionOriginally reported to inhibit PKC isoforms, especially PKCδ and CAM-KIII. Also inhibits MAPKAP-K2 and PRAK (5.4 and 1.9 μM respectively), CHK2, PLK1, PIM3 and SRPK1. |
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Useful References | |
Specificity and mechanism of action of some commonly used protein kinase inhibitors. abstract The selectivity of protein kinase inhibitors: a further update. abstract Rottlerin, a novel protein kinase inhibitor. abstract | |
Chemical Information3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone | |
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