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Ca2+ release modulator

Product Code: Asc-083

Purity: >98%

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Biological Description

Alkaloid that binds with high affinity to ryanodine receptors to modulate intracellular Ca2+ release. Has complex actions and may stimulate or inhibit Ca2+ release, depending on the concentration used.

Useful References

(1997) The pharmacology of ryanodine and related compounds. Pharmacol Rev. 49:53-98. abstract

(2002) Ryanodine receptor calcium release channels. Physiol Rev. 82:893-922 abstract

(2005) Ryanodine receptors. Cell Calcium 38:253-60 abstract


Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger abstract

Activation of metabotropic glutamate receptors induces periodic burst firing and concomitant cytosolic Ca2+ oscillations in cerebellar interneurons abstract

Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity abstract

Phosphatidylinositol 3, 5-bisphosphate (PI (3, 5) P2) potentiates cardiac contractility via activation of the ryanodine receptor abstract

Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1) abstract

Heterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles abstract

Phosphatidylinositol 3, 5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction abstract

Electrical slow waves in the mouse oviduct are dependent on extracellular and intracellular calcium sources abstract

Structural and functional conservation of key domains in InsP3 and ryanodine receptors abstract

Function and expression of ryanodine receptors and inositol 1, 4, 5‐trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles abstract

P2Y receptor subtypes evoke different Ca 2+ signals in cultured aortic smooth muscle cells abstract

Contribution of Purinergic Receptors to Calcium Signaling in Salivary Gland abstract

Effect of dexamethasone on Na+/Ca2+ exchanger in dendritic cells abstract

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes abstract

Chemical Information

1H-Pyrrole-2-carboxylic acid (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2] pentaleno[1,6-bc]furan-8-yl ester

  • Desiccate at -20°C
  • MW 493.55
  • Soluble in ethanol to 10 mM
  • C25H35NO9
  • 15662-33-6