(S)-Willardiine
AMPA / kainate receptor agonistProduct Code: Asc-040 |
Purity: >98% |
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| Buy (S)-Willardiine from Abcam | ||||
Biological DescriptionSelective AMPA receptor agonist at hGluR1 (Ki = 0.39 μM). Selective over hGluR2 (Ki = 0.90 μM), hGluR4 (Ki = 8.85 μM) and kainate receptor hGluR5 (Ki = 28.9 μM). Produces strong desensitisation. |
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Useful References | |
(1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12:595-606 abstract (1995) Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine. Neuropharmacol. 34:405-410 abstract (2002) The AMPA receptor binding site: focus on agonists and competitive antagonists. Curr.Pharm.Design 8:857-872 abstract (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem 40: 3645-50 abstract | |
Citations | |
Mankiewicz et al (2008) Chemical interplay in the mechanism of partial agonist activation in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Biochemistry. 47:398-404. abstract Structure of the S1S2 glutamate binding domain of GluR3 abstract | |
Chemical Information(S)-2-Amino-3-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)propanoic acid | |
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