SB 203580 hydrochloride

p38 MAP kinase inhibitor; water soluble

Pack Size

Biological Description Water soluble, cell permeable p38 MAP kinase inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1 , RIP2 c-Raf and GSK3.
Useful References
Kumar et al (1999) Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase. Biochem Biophys Res Commun.263:825-31 abstract Cuenda et al (2007) p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta. 1773:1358-75 abstract Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem J. 408:297-315 abstract
Chemical Information 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine hydrochloride
	Desiccate at +4°C MW 413.90 Soluble in water to 5 mM (at room temperature) and in water to 25 mM (with warming) C₂₁H₁₆FN₃OS.HCl 869185-85-3