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SB 415286

Potent, selective GSK3 inhibitor

Product Code: Asc-962

Purity: >99%

 
Pack Size

 

10mg

50mg

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Biological Description

Potent, selective GSK3 inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Neuroprotective and antioxidant properties. Also able to stimulate glycogen synthesis and gene transcription. Cell-permeable.

Useful References

Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway. abstract

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. abstract

Glycogen synthase kinase 3: a key regulator of cellular fate. abstract

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. abstract

Chemical Information

3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione

Asc-962
  • Desiccate at -20°C
  • MW 359.73
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • C16H10ClN3O5
  • 264218-23-7