SB431542

ALK inhibitor

Pack Size

Biological Description Potent and selective inhibitor of Activin Like Kinase. Inhibits ALK 4, 5 (IC₅₀ = 94 nM), and 7.
Useful References
Inman et al (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 62:65-74 abstract Halder et al (2005) A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 7:509-21 abstract Laping et al (2002) Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol.62:58-64 abstract
Chemical Information 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide
	Desiccate at RT MW 384.39 Soluble in DMSO to 100 mM and in ethanol to 10 mM C₂₂H₁₆N₄O₃ 301836-41-9