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SKF 108753 (Debromohymenialdisine)

Protein kinase inhibitor. Antineoplastic agent.

Other names: Debromohymenialdisine

Product Code: Asc-3799

 
Pack Size

 

1mg

10mg

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Biological Description

Protein kinase inhibitor. Antineoplastic agent. Inhibits Chk1 and Chk2 (IC50 values are 3 and 3.5 µM, respectively). Inhibits MAPK1 (IC50 = 881 nM) and GSK3β (IC50 = 1.39 μM). Inhibits protein tyrosine kinase 6 (IC50 = 0.6 μM). Inhibits the G2 DNA damage checkpoint (IC50 = 8 μM). Shows moderate cytotoxic effects.

Useful References

Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol. abstract

Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. abstract

Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors. abstract

Chemical Information

(4Z)-4-(2-Amino-4-oxo-1H-imidazol-5-ylidene)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one

Asc-3799
  • Desiccate at -20°C
  • MW 245.24
  • Soluble in DMSO
  • C11H11N5O2
  • 75593-17-8