SL 327

MEK inhibitor

Pack Size

Biological Description Centrally active, brain penetrant selective MEK1 and MEK2 inhibitor (IC₅₀ values in in vitro assays are 0.18 μM and 0.22 μM respectively).
Useful References
Wang et al (2003) Significant neuroprotection against ischemic brain injury of inhibition of MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther. 304: 172-178. abstract Scherle et al (2000) Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J Biol Chem. 275:37086-92 abstract Selcher et al (1999) A necessity for MAP kinase activation in mammalian spatial learning. Learn Mem. 6:478-90 abstract
Chemical Information α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
	Desiccate at +4°C MW 335.35 Soluble in DMSO to 100 mM and in ethanol to 100 mM C₁₆H₁₂F₃N₃S 305350-87-2