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SP600125

JNK inhibitor

Product Code: Asc-065

Purity: >98%

  
Pack Size

 

10mg

50mg
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Biological Description

Potent and selective JNK1, -2, and -3 inhibitor (IC50=0.11 μM). SP600125 is a reversible ATP competitive inhibitor with >20 fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα. Neuroprotective in vivo.
Useful References

Bennett et al (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A. 98:13681-6 abstract

Heo et al (2004) Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125. EMBO J. 23:2185-95. abstract

Guan et al (2006) Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain Res.1092:36-46 abstract

Citations

Caunt et al. (2008) Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases. J Biol Chem 283: 26612-26623 abstract

Chemical Information

1,9-Pyrazoloanthrone

Asc-065
  • Desiccate at +4°C
  • MW 220.23
  • Soluble in DMSO to 100 mM and in ethanol to 10 mM (with heating)
  • C14H8N2O
  • 129-56-6