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TDZD 8

Selective, non-ATP competitive GSK-3β inhibitor

Product Code: Asc-2372

Purity: >98%

 
Pack Size

 

5mg

25mg

100mg

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Biological Description

Selective, non-ATP competitive GSK-3β inhibitor (IC50 = 2 µM). Binds to the active site of GSK3β. Also inhibits PKC activity (IC50 values are 1.4, 1.1 and 5.5 µM at βI, δ and ι isoforms respectively). IC50 values are > 100 µM for Cdk-1/cyclin B, CK-II and PKA. Shows neuroprotective effects.

Useful References

Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). abstract

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. abstract

Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. abstract

Chemical Information

2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione

Asc-2372
  • Desiccate at -20°C
  • MW 222.26
  • Soluble in DMSO to 25 mM
  • C10H10N2O2S
  • 327036-89-5