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Tetrodotoxin citrate

Na+ channel blocker; water-soluble

Other names: TTX / TTX citrate

Product Code: Asc-055

Purity: >98%

Pack Size



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Biological Description

Water soluble citrate salt of tetrodotoxin. Potent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels.

Useful References

(1972) Pharmacology of tetrodotoxin and saxitoxin. Fed.Proc. 31:1117. abstract

(1994) Recent advances in the study of mechanism of action of marine neurotoxins. Neurotoxicol.15:546 abstract

Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. abstract


Role of cholinergic neurons in the motor effects of glucagon-like peptide-2 in mouse colon abstract

Ecological efficacy of chemically-mediated antipredator defenses in the Eastern newt Notophthalmus viridescens abstract

Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract abstract

Chemical Defense of the Eastern Newt (Notophthalmus viridescens): Variation in Efficiency against Different Consumers and in Different Habitats abstract

Exogenous and endogenous cannabinoids suppress inhibitory neurotransmission in the human neocortex abstract

Gastrin-releasing peptide acts via postsynaptic BB2 receptors to modulate inward rectifier K+ and TRPV1-like conductances in rat paraventricular thalamic neurons. abstract

Striatal cholinergic interneurons display activity-related phosphorylation of ribosomal protein s6. abstract

Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma. abstract

Bicuculline- and neurosteroid-sensitive tonic chloride current in rat hypoglossal motoneurons and atypical dual effect of SR95531. abstract

Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons abstract

Serotonergic modulation of neuronal activity in rat midbrain periaqueductal grey. abstract

Synaptic Zn2+ Inhibits Neurotransmitter Release by Promoting Endocannabinoid Synthesis abstract

Presynaptic NMDA Receptor Mechanisms for Enhancing Spontaneous Neurotransmitter Release abstract

Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction abstract

The Class 4 Semaphorin Sema4D Promotes the Rapid Assembly of GABAergic Synapses in Rodent Hippocampus abstract

Synaptotagmin-12 Phosphorylation by cAMP-Dependent Protein Kinase Is Essential for Hippocampal Mossy Fiber LTP abstract

hESC-derived Olig2(+) progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury. abstract

Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine. abstract

Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus abstract

Melanocortin Signaling in the Brainstem Influences Vagal Outflow to the Stomach abstract

Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. abstract

The dual effect of PNU-120596 on ?7 nicotinic acetylcholine receptor channels. abstract

Bladder contractility is modulated by Kv7 channels in pig detrusor. abstract

NaV1.1 Channels in Axon Initial Segments of Bipolar Cells Augment Input to Magnocellular Visual Pathways in the Primate Retina abstract

Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation abstract

Identification of CaV channel types expressed in muscle afferent neurons abstract

Chemical Information

Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol + citrate buffer

  • Desiccate at -20°C
  • MW 319.27
  • Soluble in water
  • C11H17N3O8
  • 18660-81-6
Additional Information

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