Thapsigargin
Ca2+-ATPase inhibitorProduct Code: Asc-286 |
Purity: >98% |
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Biological DescriptionA potent, cell-permeable Ca2+-ATPase inhibitor. Releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Both tumorogenic and apoptotic actions reported. |
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Useful References | |
Treiman et al (1998) A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases. Trends Pharmacol .19(4):131-5. abstract Thastrup et al (1989) Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions. 27:17-23. abstract Inesi et al (1992) Thapsigargin, a high affinity and global inhibitor of intracellular Ca2+ transport ATPases.Arch Biochem Biophys. 298:313-7. abstract | |
Chemical Information(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate | |
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