Topotecan hydrochloride (SK&F 104864)

Topoisomerase inhibitor

Pack Size

Biological Description Topoisomerase I inhibitor. Water-soluble derivative of camptothecin (Asc-115). Anticancer agent.
Useful References
Mathijssen et al (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan. Curr Cancer Drug Targets. 2:103-23. abstract Tanizawa et al (1994) Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst. 86:836-42. abstract
Chemical Information (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride
	Desiccate at -20°C MW 457.91 Soluble in water to 100 mM and in DMSO to 100 mM C₂₃H₂₃N₃O₅.HCl 119413-54-6