Home > Tunicamycin from Streptomyces sp 

Tunicamycin from Streptomyces sp

Antibiotic. Protein glycosylation inhibitor

Product Code: Asc-296

Purity: >99%

  
Pack Size

 

10mg

50mg
Buy Tunicamycin from Streptomyces sp from Abcam
Biological Description

Nucleoside antibiotic that inhibits protein glycosylation. Inhibits GlcNAc phosphotransferase (GPT) and inhibits the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses.
Useful References

Duksin et al (1982) Relationship of the structure and biological activity of the natural homologues of tunicamycin. J Biol Chem. 257:3105-9 abstract

Price et al (2007) Biosynthesis of the tunicamycins: a review. J Antibiot (Tokyo). 60:485-91 abstract

Chemical Information

 

Asc-296
  • Desiccate at +4°C
  • MW 844.95
  • Soluble in DMSO to 50 mM
  • C39H64N4O16(for tunicamycin C, n=10)
  • 11089-65-9
Additional Information

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