U0126
Selective MKK inhibitorProduct Code: Asc-241 |
Purity: >98% |
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| Buy U0126 from Abcam | ||||
Biological DescriptionSelective non-competitive inhibitor of MAP kinase kinase (MKK). Inhibits MKK1, MKK2 (IC50 values of 0.07 and 0.06 μM respectively) and MKK5 with little or no effect on a wide range of other kinases. Centrally active following systemic administration in vivo. |
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Useful References | |
Favata et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 273:18623-32 abstract Duncia et al (1998) MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 8:2839-44 abstract Bain et al (2007)The selectivity of protein kinase inhibitors: a further update. Biochem J. 408:297-315 abstract | |
Chemical Information1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene | |
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