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VU 0360223

Potent mGlu5 antagonist

Product Code: Asc-803

Purity: >98%

Pack Size




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Biological Description

Negative allosteric mGlu5 modulator (IC50 = 61 nM). Inactive against mGlu1-4 and mGlu7-8. Centrally active and crosses the blood-brain barrier.

Useful References

(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. abstract

Chemical Information


  • Store at RT
  • MW 268.31
  • Soluble in DMSO to 25 mM
  • C15H9FN2S
  • 1274859-33-4