VU0155041 sodium salt
PAM for mGluR4 (water soluble)Product Code: Asc-248 |
Purity: >99% |
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| Buy VU0155041 sodium salt from Abcam | ||||
Biological DescriptionWater soluble, positive allosteric selective modulator at mGluR4 (EC50 values are 798 nM and 693 nM at human and rat mGluR4 receptors respectively). It has advantages over PHCCC (Asc-043) as it is water soluble and more potent. Shows limited blood brain barrier permeability. Active in behavioural models of Parkinson's disease following icv injection. |
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Useful References | |
(2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 74:1345-58. abstract (2009) Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorg Med Chem Lett. 19:4967-70. abstract | |
Chemical Informationcis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt | |
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