Wortmannin

PI3-kinase inhibitor

Product Code: Asc-148

Purity: >98%

Pack Size

1mg

5mg

Buy Wortmannin from Abcam

Biological Description

Potent, selective and cell permeable inhibitor of phosphatidylinositol-3-kinase (PI3-kinase) (IC₅₀ ~ 3 nM)

Useful References

Ui et al (1995) Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem Sci. 20:303-7 abstract

Hazeki et al (1996) Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events. J Lipid Mediat Cell Signal. 14:259-61 abstract

Wipf et al (2005) Chemistry and biology of wortmannin. Org Biomol Chem. 3:2053-61 abstract

Chemical Information

(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,h]-2-h]-2-benzopyran-3,6,9-trione

Desiccate at -20°C
MW 428.43
Soluble in DMSO to 50 mM
C₂₃H₂₄O₈
19545-26-7

Additional Information

Country restrictions and/or license requirements may apply. Please contact customer services for further details.