Y-27632 dihydrochloride
Selective Rho kinase inhibitorProduct Code: Asc-129 |
Purity: >99% |
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| Buy Y-27632 dihydrochloride from Abcam | |||||
Biological DescriptionPotent, selective Rho kinase inhibitor. (Ki values are 0.22, 0.30, 73, 25, >250 μM for ROCKI, ROCKII, PKCα, PKA and MLCK respectively). Muscle relaxant. Systemically active antinociceptive. Increases human embryonic stem (hES) cell survival, inhibiting apoptosis. |
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Useful References | |
Darenfed et al (2007) Molecular characterization of the effects of Y-27632. Cell Motil Cytoskeleton. 64:97-109 abstract Ishizaki et al (2000) Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 57:976-83 abstract Buyukafsar et al (2006) Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice. Eur J Pharmacol. 541:49-52 abstract A ROCK inhibitor permits survival of dissociated human embryonic stem cells. abstract An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. abstract | |
Chemical Information(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride | |
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