Z-D(OMe)E(OMe)VD(OMe)-FMK
Cell permeable caspase-3 inhibitorOther names: Caspase-3 Inhibitor / Z-DEVD-FMK (cell permeable) | |||||
Product Code: Asc-488 |
Purity: >90% |
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| Buy Z-D(OMe)E(OMe)VD(OMe)-FMK from Abcam | ||||
Biological DescriptionA potent, cell-permeable, and irreversible inhibitor of caspase-3. Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10. Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. Therefore, when using with isolated, purified or recombinant caspase enzymes, pre-treatment with an esterase is required. |
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Useful References | |
Central administration of a caspase inhibitor impairs shuttle-box performance in rats. abstract Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. abstract Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. abstract | |
Chemical InformationN-Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone | |
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