Z-VAD(OMe)-FMK
Cell permeable, irreversible pan-caspase inhibitorOther names: Z-VAD-FMK (cell permeable) | |||||
Product Code: Asc-487 |
Purity: >90% |
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| Buy Z-VAD(OMe)-FMK from Abcam | ||||
Biological DescriptionA cell-permeable, irreversible, pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro. Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. Therefore, when using with isolated, purified or recombinant caspase enzymes, pre-treatment with an esterase is required. |
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Useful References | |
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. abstract A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice. abstract Amyloid Precursor Protein Binding Protein Fe65 Is Cleaved by Caspases during DNA Damage-Induced Apoptosis. abstract | |
Chemical InformationN-Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone | |
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