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ZM 241385

Potent, selective A2A antagonist

Product Code: Asc-218

Purity: >99%

  
Pack Size

 

10mg

50mg
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Biological Description

Potent A2 adenosine receptor antagonist, with approx 50-fold selectivity for A2A receptors. (Ki values are <1 nM, 50 nM, 255 nM and >10 μM at human cloned A2A, A2B, A1 and A3 receptors respectively). Orally active in vivo.
Useful References

(1995) The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist. Br J Pharmacol. 115:1096-102 abstract

(1996) In vivo characterisation of ZM 241385, a selective adenosine A2A receptor antagonist. Eur J Pharmacol. 301:107-13 abstract

(1999) Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 359:7-10 abstract

Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists. abstract

Chemical Information

4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol

Asc-218
  • Store at RT
  • MW 337.34
  • Soluble in DMSO to 100 mM and in ethanol to 5 mM (with warming)
  • C16H15N7O2
  • 139180-30-6