ZM 336372

Potent, selective c-Raf inhibitor

Pack Size

Biological Description Potent, cell permeable and selective c-Raf inhibitor (IC₅₀= 70 nM). Displays 10 fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.
Useful References
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. abstract Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. abstract Paradoxical activation of Raf by a novel Raf inhibitor. abstract
Chemical Information 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide
	Store at +4°C MW 389.45 Soluble in DMSO to 100 mM C₂₃H₂₃N₃O₃ 208260-29-1