PHCCC Selective allosteric potentiator at mGlu₄ . Also group I antagonist.

Biological Description Selective allosteric potentiator of mGlu₄. Anti-Parkinson and anxiolytic effects in vivo. Also antagonist at Group I metabotropic receptors.
Useful References Marino et al (2003) Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc.Natl.Acad.Sci. 100:13668-73 abstract Stachowicz et al (2004) Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats. Eur. J. Pharmacol. 498:153-6. abstract Annoura et al (1996) A novel class of antagonists for metabotropic glutamate receptors, 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett. 6:763-766
Chemical Information (E)-1,1a,7,7a-Tetrahydro-7-(hydroxyimino)-N-phenylcyclopropa[b]chromene-1a-carboxamide
	Desiccate at +4°C MW 294.31 Soluble to 100 mM in DMSO and to 5 mM in water C₁₇H₁₄N₂O₃

PHCCC Selective allosteric potentiator at mGlu4 . Also group I antagonist.