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Selective allosteric potentiator at mGlu4. Also group I antagonist.

Product Code: Asc-043

Purity: >98%

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Biological Description

Selective allosteric potentiator of mGlu4. Anti-Parkinson and anxiolytic effects in vivo. Also antagonist at Group I metabotropic receptors.

Useful References

(2003) Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc.Natl.Acad.Sci. 100:13668-73 abstract

(2004) Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats. Eur. J. Pharmacol. 498:153-6. abstract

(1996) A novel class of antagonists for metabotropic glutamate receptors, 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg.Med.Chem.Lett. 6:763-766 abstract


Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain abstract

mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner abstract

Chemical Information


  • Desiccate at +4°C
  • MW 294.31
  • Soluble in DMSO to 100 mM
  • C17H14N2O3