Herkinorin

Non-internalising μ opioid agonist

Pack Size

Biological Description Selective μ opioid receptor agonist derived from the plant product, salvinorin A (Asc-084). Does not promote the recruitment of beta-arrestin-2 or lead to receptor internalization.
Useful References
(2007) A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence. Synapse. 61:166-75 abstract (2007) An opioid agonist that does not induce micro-opioid receptor--arrestin interactions or receptor internalization. Mol Pharmacol. 71:549-57 abstract (2006) Synthesis of salvinorin A analogues as opioid receptor probes. J Nat Prod. 69:914-8 abstract
Chemical Information (2S,4aR,6aR,7R,9S,10aS,10bR)-Methyl 9-(benzoyloxy)-2-(furan-3-yl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-1H-benzo[f]isochromene-7-carboxylate
	Desiccate at +4°C MW 494.53 Soluble in DMSO to 100 mM C₂₈H₃₀O₈