VU0155041 PAM for mGluR4

Biological Description Positive allosteric selective modulator at mGluR4 (EC₅₀ values are 798 nM and 693 nM at human and rat mGluR4 receptors respectively). It has advantages over PHCCC (Asc-043) as it is more potent. Active in behavioural models of Parkinsons Diseas
Useful References Niswender et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol 2008 Jul 29. [Epub ahead of print] abstract
Chemical Information cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid
	Store at RT MW 316.18 Soluble in 100mM NaOH to 100mM, in DMSO to 100mM and in ethanol to 50mM C₁₄H₁₅Cl₂NO₃