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VU0155041

PAM for mGluR4

Product Code: Asc-244

Purity: >99%

 
Pack Size

 

10mg

50mg

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Biological Description

Positive allosteric selective modulator at mGluR4 (EC50 values are 798 and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (Asc-043) as it is more potent. Shows limited blood-brain barrier permeability. Active in behavioural models of Parkinson's disease following icv injection. Available in water-soluble form - please see VU0155041 sodium salt (Asc-248).

Useful References

(2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol 2008 Jul 29. [Epub ahead of print] abstract

Citations

Allosteric modulation of the group III mGlu receptor 4 provides functional neuroprotection in the 6?OHDA rat model of Parkinson's disease. abstract

Chemical Information

cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid

Asc-244
  • Store at RT
  • MW 316.18
  • Soluble in 1 eq. NaOH to 100 mM, in DMSO to 100 mM and in ethanol to 50 mM
  • C14H15Cl2NO3