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VU0155041 sodium salt

PAM for mGluR4; water soluble

Product Code: Asc-248

Purity: >98%

 
Pack Size

 

10mg

50mg

Buy VU0155041 sodium salt from Abcam
Biological Description

Positive allosteric selective modulator at mGluR4 (EC50 values are 798 and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is water soluble and more potent. Shows limited blood-brain barrier permeability. Active in behavioural models of Parkinson's disease following icv injection.

Also available in simple stock solutions (ab146686) - add 1 ml of water to get an exact, ready-to-use concentration.

Useful References

(2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 74:1345-58. abstract

(2009) Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorg Med Chem Lett. 19:4967-70. abstract

Chemical Information

cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt

Asc-248
  • Store at RT
  • MW 338.16
  • Soluble in water to 100 mM
  • C14H14Cl2NNaO3