VU0155041 sodium salt PAM for mGluR4 (water soluble)

Biological Description Water soluble, positive allosteric selective modulator at mGluR4 (EC₅₀ values are 798 nM and 693 nM at human and rat mGluR4 receptors respectively). It has advantages over PHCCC (Asc-043) as it is water soluble and more potent. Active in behavi
Useful References Niswender et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 74:1345-58. abstract Williams et al (2009) Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorg Med Chem Lett. 19:4967-70. abstract
Chemical Information cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt
	Store at RT MW 338.16 Soluble to 100 mM in water C₁₄H₁₄Cl₂N