YM 202074 mGlu₁ antagonist

Biological Description Potent, selective allosteric mGluR1 antagonist. Binds to an allosteric site of rat mGluR1 with a K_i value of 4.8 nM. Neuroprotective in vivo.
Useful References Kohara et al (2008) Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models. Brain Res. 1191:168-79. abstract
Chemical Information N-Cyclohexyl-6-[[(2-methoxyethyl)methylamino]methyl]-N-methyl-thiazolo[3,2-a]benzimidazole-2-carboxamide
	Desiccate at +4°C MW 414.56 Soluble in water to 25mM with heating/stirring and in DMSO to 100mM C₂₂H₃₀N₄O₂S 299900-83-7

YM 202074 mGlu1 antagonist