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FFN511

Fluorescent false neurotransmitter; highly efficient optical tracer of dopamine

Other names: Fluorescent False Neurotransmitter 511

Product Code: Asc-331

Purity: >99%

  
Pack Size

 

1mg

5mg
Buy FFN511 from Abcam
Biological Description

A novel, fluorescent probe for optical imaging and measurement of synaptic activity in the brain. This Fluorescent False Neurotransmitter (FFN) acts as a substrate for the synaptic vesicle monoamine transporter (VMAT2). FFN511 fluoresces sufficiently to provide resolution at the individual synaptic level but at concentrations that do not interfere with normal synaptic function. Inhibits 5HT binding to VMAT2 with an IC50 of 1 μM (comparable to dopamine itself). Compatible with GFP-based tags and other optical probes. View the technique online
Useful References

(2009). Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science 324:1441-4. abstract

(2009) Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs. Journal of Visualized Experiments 30. abstract

Chemical Information

9-(2-Aminoethyl)-2,3,6,7-tetrahydro-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizin-11-one

Asc-331
  • Desiccate at +4°C
  • MW 284.36
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • C17H20N2O2
  • 1004548-96-2
Additional Information

Sold under license from Columbia University; Patent Pending