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FFN511

First novel fluorescent false neurotransmitter. Enables optical imaging of presynaptic terminal activity.

Other names: Fluorescent False Neurotransmitter 511

Product Code: Asc-331

Purity: >99%

 
Pack Size

 

1mg

5mg

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Biological Description

First novel fluorescent false neurotransmitter. Enables optical imaging of presynaptic terminal activity.
Inhibits 5-HT binding to VMAT2 (IC50 = 1 µM (comparable to dopamine itself)). Released via exocytosis in the striatum in mouse acute slice preparation. Labels dopamine and other presynaptic terminals in the striatum.
Compatible with GFP tags and other optical probes. Sufficiently bright, photostable and suitable for two-photon fluorescence microscopy.
View the technique online

For highly selective labelling of dopaminergic presynaptic termainals FFN102 (Asc-866) is recommended.

Useful References

(2009). Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science 324:1441-4. abstract

(2009) Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs. Journal of Visualized Experiments 30. abstract

Chemical Information

9-(2-Aminoethyl)-2,3,6,7-tetrahydro-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizin-11-one

Asc-331
  • Desiccate at +4°C
  • MW 284.36
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • C17H20N2O2
  • 1004548-96-2