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Novel caged-glutamate compound, uncaged by visible light

Product Code: Asc-408

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Biological Description

Novel caged-glutamate compound based on ruthenium photochemistry. Excited with visible wavelengths and releases glutamate after one- or two-photon excitation. It has high quantum efficiency and can be used at low concentrations. Enables the photoactivation of neuronal dendrites and circuits with visible or two-photon light sources, achieving single cell, or even single spine, precision.

Also available in simple stock solutions (ab146718) - add 1 ml of water to get an exact, ready-to-use concentration.

Useful References

(2009) RuBi-Glutamate: Two-Photon and Visible-Light Photoactivation of Neurons and Dendritic spines. Front Neural Circuits. 2009;3:2 abstract

(2010) A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes. J Inorg Biochem. 104:418-22 abstract

Chemical Information

(Bis(2,2'-bipyridine-N,N')trimethylphosphine)-(S)-1-aminopropane-1,3-dicarboxylic acid ruthenium(2+) complex sodium hexafluorophosphate salt

  • Desiccate at -20°C
  • MW 948.56
  • Soluble in water to 20 mM
  • C28H33N5O4PRu.Na(PF6)2
Additional Information

Sold under license from Columbia University; Patent Pending