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Novel caged-GABA compound, uncaged by visible light

Product Code: Asc-409

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Biological Description

Novel caged-GABA compound that uses a ruthenium complex as photosensor. Can be excited with visible wavelengths, providing greater tissue penetration, less photo-toxicity, and faster photorelease kinetics than other UV light-sensitive caged compounds. Can be used for GABA receptor mapping, and optical silencing of neuronal firing.

Useful References

(2008) Photorelease of GABA with Visible Light Using an Inorganic Caging Group. Front Neural Circuits. 2:2 abstract

(2007) A new inorganic photolabile protecting group for highly efficient visible light GABA uncaging. Chembiochem. 8:2035-8. abstract


The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines abstract

Chemical Information

(Bis(2,2'-bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex

  • Desiccate at -20°C
  • MW 922.80
  • Soluble in DMSO to 25 mM. For water solubility, please refer to Guideline for Use Information Sheet
  • C42H39N5O2PRu.PF6
Additional Information

Sold under license from Columbia University; Patent Pending