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Caged K+ channel blocker, uncaged by visible light

Product Code: Asc-410

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Biological Description

Water soluble caged 4-aminopyridine (4-AP) based on ruthenium photochemistry. Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases voltage-dependent K+ channel blocker 4-aminopyridine (Asc-122) when uncaged.

Useful References

(2003) A new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage. J Am Chem Soc. 125:882-3. abstract

(2005) Two-photon uncaging of neurochemicals using inorganic metal complexes. Chem Commun 7:1752-4. abstract

Chemical Information

Bis(2,2'-bipyridine-N,N')bis(4-aminopyridine-N1) ruthenium(2+) dichloride complex

  • Desiccate at -20°C
  • MW 672.58
  • Soluble in water
  • C30H28Cl2N8Ru
Additional Information

Sold under license from Columbia University; Patent Pending